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DTSTAMP:20210916T132528Z
LOCATION:Henry Dunant
DTSTART;TZID=Europe/Stockholm:20210705T153000
DTEND;TZID=Europe/Stockholm:20210705T173000
UID:submissions.pasc-conference.org_PASC21_sess121@linklings.com
SUMMARY:In-Silico Medicine
DESCRIPTION:Minisymposium\n\nComputer models and HPC simulations are becom
 ing a very important approach to assist clinicans in treating diseases and
  devising new therapies. The goal of this minisymposium is to investigate 
 several challenges associated with this approach. We will propose a select
 ion of talks inspired by the problems raised in the H2020 project INSIST, 
 for instance the estimation of success scores of a medical intervention th
 rough modeling (e.g. thrombolysis and thrombectomy processes in the treatm
 ent of a stroke, the impact of the lack of oxygen in the brain), and the w
 ay to build a virtual population of patients to propose new treatments and
  avoid in-vivo and in-vitro experiments. The problem of validation and unc
 ertainty quantification of the numerical models will also be considered.\n
 \nLattice-Boltzmann Mesoscopic Fibrinolysis\n\nPetkantchin, Raynaud, Chopa
 rd\n\nIschemic stroke disease is the 1st cause of disability and 3rd cause
  of death in civilized countries. Treatment options are thrombolysis and t
 hrombectomy. The latter consists in the mechanical removal of the blood cl
 ot, through surgery. The former, consists in the chemical breakdown of the
  clot, by ...\n\n---------------------\nIn-silico Modelling of the Impact 
 of Ischaemic Stroke on the Human Brain\n\nPayne\n\nThe rising clinical inc
 idence of cerebrovascular diseases, such as stroke and dementia, mean that
  understanding cerebral blood flow and its control in both healthy and dis
 eased states has become an important clinical problem. However this is mad
 e highly challenging by the spatial and temporal limita...\n\n------------
 ---------\nA Low Dimensional Surrogate Model of High-Fidelity Simulations 
 of Intra-Arterial Thrombectomy\n\nBridio, Rodriguez Matas\n\nThe technique
  of surrogate modelling consists in reproducing the behavior of a physical
  system by finding a mapping between a set of input and output data produc
 ed by the system. In this work, the surrogate modelling technique was appl
 ied to reproduce the behavior of high-fidelity simulations of the...\n\n--
 -------------------\nDesign and Implementation of In-Silico Trials for Acu
 te Ischemic Stroke\n\nHoekstra, Miller, van der Kolk, Padmos\n\nIn silico 
 trials are patient-specific simulations on a cohort of virtual patients to
  support the development and evaluation of medical devices, drugs and trea
 tment. In silico trials have the potential to refine, reduce cost, and par
 tially replace current clinical trials or animal experimentation. We...\n\
 n\nDomain: CS and Math, Chemistry and Materials, Physics, Life Sciences, E
 ngineering
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