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DTSTAMP:20210916T132448Z
LOCATION:Henry Dunant
DTSTART;TZID=Europe/Stockholm:20210705T163000
DTEND;TZID=Europe/Stockholm:20210705T170000
UID:submissions.pasc-conference.org_PASC21_sess121_msa250@linklings.com
SUMMARY:In-silico Modelling of the Impact of Ischaemic Stroke on the Human
  Brain
DESCRIPTION:Minisymposium\n\nIn-silico Modelling of the Impact of Ischaemi
 c Stroke on the Human Brain\n\nPayne\n\nThe rising clinical incidence of c
 erebrovascular diseases, such as stroke and dementia, mean that understand
 ing cerebral blood flow and its control in both healthy and diseased state
 s has become an important clinical problem. However this is made highly ch
 allenging by the spatial and temporal limitations of human brain imaging a
 nd the number of blood vessels involved in a what is a highly complex dyna
 mic regulating system over many length scales. In this talk I will discuss
  the work that we have done to construct models of both cerebral blood flo
 w and oxygen transport that cover the many length scales involved, running
  from a few micrometres to a few millimetres. I will show how we have deve
 loped such models from the bottom up, through highly detailed modelling of
  the microcirculation and the application of homogenisation and optimisati
 on methods, in order to generate a full-brain model of blood flow and oxyg
 en transport. I will then focus on how this can be applied (and valid
 ated) in the context of ischaemic stroke to simulate the impact of both is
 chaemic stroke and its treatment on the human brain.\n\nDomain: CS and Mat
 h, Chemistry and Materials, Physics, Life Sciences, Engineering
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