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DTSTAMP:20210916T132447Z
LOCATION:Lise Girardin
DTSTART;TZID=Europe/Stockholm:20210709T113000
DTEND;TZID=Europe/Stockholm:20210709T120000
UID:submissions.pasc-conference.org_PASC21_sess190_pap_aug102@linklings.co
 m
SUMMARY:Evaluating the Influence of Hemorheological Parameters on Circulat
 ing Tumor Cell Trajectory and Simulation Time
DESCRIPTION:Paper\n\nEvaluating the Influence of Hemorheological Parameter
 s on Circulating Tumor Cell Trajectory and Simulation Time\n\nRoychowdhury
 , Gounley, Randles\n\nExtravasation of circulating tumor cells (CTCs) occu
 rs primarily in the microvasculature, where flow and cell interactions sig
 nificantly affect the blood rheology. Capturing cell trajectory at this sc
 ale requires the coupling of several interaction models, leading to increa
 sed computational cost that scales as more cells are added or the domain s
 ize is increased. In this work, we focus on micro-scale vessels and study 
 the influence of certain hemorheological factors, including the presence o
 f red blood cell aggregation, hematocrit level, microvessel size, and shea
 r rate, on the trajectory of a circulating tumor cell. We determine which 
 of the aforementioned factors significantly affect CTC motion and identify
  those which can potentially be disregarded, thus reducing simulation time
 . We measure the effect of these elements by studying the radial CTC movem
 ent and runtime at various combinations of these hemorheological parameter
 s. To accurately capture blood flow dynamics and single cell movement, we 
 perform high-fidelity hemodynamic simulations at a sub-micron resolution u
 sing our in-house fluid dynamics solver, HARVEY. We find that increasing h
 ematocrit increases the likelihood of tumor cell margination, which is exa
 cerbated by the presence of red blood cell aggregation. As microvessel dia
 meter increases, there is no major CTC movement towards the wall; however,
  including aggregation causes the CTC to marginate quicker as the vessel s
 ize increases. Finally, as the shear rate is increased, the presence of ag
 gregation has a diminished effect on tumor cell margination.\n\nDomain: CS
  and Math, Physics, Life Sciences
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